Simon Mignolet replaces Loris Karius in goal.
In defence Joe Gomez, Joel Matip, Ragnar Klavan and Alberto Moreno get the nod.
In midfield skipper Jordan Henderson misses out through injury while Emre Can starts. Georginio Wijnaldum is fit enough to start despite being injured against Maribor in midweek. Alex Oxlade-Chamberlain gets another chance to show what he can do starting a second game in a row for the Reds.
Mane returns to join Firmino and Salah in attack.
Liverpool Team: Mignolet, Gomez, Matip, Klavan, Moreno, Can, Wijnaldum, Oxlade-Chamberlain, Salah, Mane, Firmino.
Subs: Karius, Alexander-Arnold, Lovren, Milner, Grujic, Sturridge, Solanke.
West Ham v Liverpool FC in the Premier League kicks off at the London Stadium at 17:30 GMT on Saturday 4 November.