Liverpool Team: Karius, Gomez, Klavan, Lovren, Moreno, Wijnaldum, Henderson, Coutinho, Mane, Salah, Firmino.
Subs: Mignolet, Milner, Sturridge, Oxlade-Chamberlain, Can, Solanke, Alexander-Arnold.
Loris Karius starts in goal, and Joe Gomez replaces Trent Alexander-Arnold at right-back, while Klavan and Lovren continue in central defence.
Philippe Coutinho, Sadio Mane, Mohamed Salah and Roberto Firmino all start.
Joel Matip is out with a thigh injury and has not travelled to Spain.
Sevilla scored a late equaliser in the opening group game at Anfield as it finished 2-2.
Sevilla v Liverpool in Group E of the Champions League kicks off at the Ramón Sánchez-Pizjuán Stadium at 19:45 on Tuesday 21 November.